Sr. Scientist​/Principal Scientist, Bioassays, Biologics Analytical Development

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis
* and uterine fibroids,
* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science.

For more information, visit , and follow the company on Linked In, X and Facebook. (
* in collaboration with Abb Vie)

About the Role:

This Scientist will guide the design, development, and execution of cell-based and molecular biology methods for the characterization and analysis of gene therapy and other biologic-based assets for research, pre-clinical, and clinical use. They will collaborate with CMC analytical development & therapeutic area leads in analysis to determine the content and potency properties of proteins and gene therapy vectors, working cross-functionally to establish the laboratory standards for determining strength, potency and quality attributes for these late-stage discovery and early development candidates.

• Supports activities associated with the development and execution of cell-based methods relevant to protein and gene therapy products for analytical development in a research and development pre-clinical environment.

• Establishes assay development parameters such as specificity, linearity, precision, and repeatability of biological assays through optimization of experimental methods.

• Leads the timely transfer of the developed assay to CMC/external vendor for QC testing and co-manage external assay development/qualification for release and stability testing of potency at the CROs.

• Performs molecular biology techniques (MSD, Western blotting, DNA/RNA extractions, Digital PCR, RT-PCR, quantitative PCR, etc.).

• Identifies, evaluates, and champions new enabling technologies and experimental methods.

• Performs rigorous data analysis and provides timely reports/presentations to project teams.

• Properly documents experimental designs, findings, and assay protocols, and complies with all laboratory trainings and safety requirements.

• Works with a cross-functional team to maintain cell lines for biologically based potency assays for Gene Therapy products, specifically AAV.

• Contributes through authorship and review of documents for the development and establishment of analytical methods for product characterization to support research and development activities including the in-process and release testing for material manufactured for research, GLP toxicology and IND-enabling studies.

• Represents the group during discussions with Research, Development, and collaborative stakeholders to build scientific knowledge, capabilities, and strategies by providing protein and gene therapy product characterization data to support research and product development decisions.

• Contributes to the development of, and effective execution of, science-driven, phase appropriate, and risk-based process development strategies to support development projects in discovery and development phase programs to lead candidate nomination with responsibility to help tech transfer activities for further GMP assay development, testing.

• Contributes to the decision-making processes within each project team by actively engaging in scientific and technical discussions.

• Performs other duties as assigned.

• Principal Scientist Level: BA/BS in Biochemistry, Biology, or other relevant discipline and 8+ years of Biotechnology industry experience in biologics including gene therapy-specific techniques OR Master's/PhD in relevant discipline and 6+ years as noted above.

• PhD or equivalent and 4+ years of relevant experience; may include postdoc experience, Gene Therapy positions will require a PhD in Pharmacology, Neuroscience, Endocrinology, Physiology, or closely related discipline.

• Sr. Scientist Level: BA/BS in Biochemistry, Biology, or other relevant discipline and 4+ years of Biotechnology industry experience in biologics including gene…